Last application date: Sep 15, 2019 11:47
Department: GE31 - Department of Biomolecular Medicine
Employment category: Research staff group 1
Contract: Limited duration
Degree: Master of Science in Bioscience Engineering, Master of Science in Biomedical Sciences, Master of Science in Biochemistry and Biotechnology, Master of Medicine, Master of Science in Pharmaceutical Sciences
Occupancy rate: 100%
Vacancy Type: Research staff
A position is available in the research team on heritable thoracic aortic diseases (HTAD) at Ghent University, supervised by Prof. Dr. Julie De Backer and Dr. Patrick Sips (https://www.cmgg.be/en/research/connective-tissue/aortic-aneurysm), for a highly motivated, driven researcher with a strong interest in genetics and cardiovascular disease, and basic knowledge in the use of preclinical models. Since the advent of the latest DNA sequencing technologies, the clinical implementation of precision medicine for genetic disorders has come within reach. Nevertheless, the availability of relevant functional models to test the effects of newly discovered genetic variants has become a major bottleneck in medical genetics. On the other hand, suitable functional models are necessary for the discovery and validation of new treatment options. In order to address these issues in the framework of our focus on HTAD, you will be engaged in an ongoing preclinical research project. You will develop novel zebrafish models using genome editing technology to be able to perform genetic and pharmacologic screening programs. As a complementary model, you will also use existing genetically modified mouse models to validate results from the zebrafish screens and to test several new treatment options to alleviate the symptoms of HTAD. The techniques used in this project include CRISPR/Cas-based gene editing, advanced brightfield and fluorescence microscopy, in vivo high-throughput screening, mouse and zebrafish echocardiography, immunohistochemistry, Western blotting, and QPCR.
Applications including a CV with a description of research output and motivation letter should be sent electronically to firstname.lastname@example.org.
Top-ranked candidates will be invited for an interview (either on-site or via Skype) during the first two weeks of September.
Starting date will be determined in agreement with the candidate.Continue reading
|Title||Predoctoral researcher - Department of Biomolecular Medicine|
|Job location||Sint-Pietersnieuwstraat 33, 9000 Gent|
|Published||June 25, 2019|
|Application deadline||September 15, 2019|
|Job types||PhD  |
|Fields||Biotechnology,   Biomedical Engineering,   Biomedicine,   Biochemistry,   Genetics,   Histology,   Immunochemistry,   Bioengineering,   Pharmacy & Pharmacology,    and 1 more. Molecular Medicine  |