ampere University and Tampere University of Applied Sciences create a unique environment for multidisciplinary, inspirational and high-impact research and education. Our universities community has its competitive edges in technology, health and society. www.tuni.fi/en
The CROSSHARES consortium, funded by the Academy of Finland, aims to understand the role of mitochondrial-nuclear compatibility in species differentiation https://www.uef.fi/web/hare-research. The consortium associates the Mitochondrial Metabolism Group led by Dr. E. Dufour at the University of Tampere (where this doctoral position is offered) , the Hare Research Group led by Dr. J Pohjoismäki at the University of Eastern Finland in Joensuu, as well as at the Evolutionary Biology Group led by Steve Smith at the University of Vienna.
This project will offer excellent opportunities for PhD students to learn basic and advanced methods in molecular and cellular biology, to use a broad range of state-of-the-art biochemical and biotechnological methods and to acquire knowledge in the bioinformatics tools used in genomics.
We are now seeking a Doctoral researcher in Molecular and Cellular Biology. The candidate will be offered the opportunity of funded participation in specialized workshops as well as to present his/her findings at national and international meetings.
We are looking for a Doctoral Researcher (PhD student) with interest in:
Interest in evolutionary biology, bioinformatics and genomics are a plus.
Successful candidates will pursue a doctoral degree at Tampere University. Full-time doctoral studies are expected to be completed in four years.
The main task of the doctoral student will be to study the cell biology of cybrid cell lines in which mitochondrial and nuclear genomes have been reshuffled. The candidate will use a variety of techniques including live confocal imaging, flow cytometry, advanced respirometry as well as classical molecular and cellular biology techniques.
The main research focus will be to analyze mitochondrial-nuclear compatibility. The PhD student will measure the molecular and physiological effects caused by the exchange of mitochondrial DNA (mtDNA) between the brown hares (Lepus europaeus) and mountain hares (L. timidus). In practice, this means measuring the effect of the interchanged mtDNA and nuclear genomes on cell growth, viability, metabolic requirements; on oxidative phosphorylation, mitochondrial function and stability; and on gene expression as well as cellular signaling. The PhD student will use his/her results to isolate the genes involved in nucleo-mitochondrial compatibility. The role of the candidate genes will be further dissected using targeted knock-in by Crispr/Cas9 and/or ectopic expression.
You need to have finished or being finishing (last year of studies) a Master’s degree in cell biology, molecular biology or a related field during the year 2020 and have demonstrated (during your studies towards the Master’s degree or otherwise) the competence and motivation to pursue postgraduate studies.
Successful candidates must be pursuing or willing to study towards a doctoral degree in the doctoral program of the discipline starting latest in 2021. Please visit the admissions webpage for more information on eligibility requirements.
Candidates are selected based on the level of promise that they show, and this will be evaluated on the basis of the letter of motivation, their previous success in studies and research, possible scientific publications, and other relevant experience.
English will be used as the language of instruction and supervision in this position.
The position will be filled for a fixed-term period of maximum four (4) years. The starting date is the 2nd of March 2020, or as mutually agreed. A trial period of six (6) months applies to all our new employees.
The salary of the position is determined in accordance with the salary system of Finnish universities and is based on level 2-4 of the job requirement level chart for teaching and research staff (€2,033.29 - €2,535.20/ month). In addition to the job requirement component, the salary will include a personal performance component, to be negociated, which may be a maximum of 50.0% of the job requirement component. The salary increases with experience.
We offer a wide range of staff benefits, such as occupational health care, flexible working hours, excellent sports facilities on campus and several restaurants and cafés on campus with staff discounts. Please read more about working at Tampere University.
HOW TO APPLY
Please submit your application through our online recruitment system. The closing date for applications is 20.2.2020 (23:59 EEST (GMT+3)).
Please write your application and all the accompanying documentation in English and attach them in PDF format.
Please attach only the following documents to your application:
For further information, please contact:
Research Group Leader Eric Dufour, email@example.com, tel. +358 400 316504.Continue reading
|Title||Doctoral Researcher (Molecular and Cellular Biology)|
|Job location||Kalevantie 4, 33100 Tampere|
|Published||January 22, 2020|
|Application deadline||February 20, 2020|
|Job types||PhD  |
|Fields||Molecular Biology,   Cell Biology  |