The potential candidate will be expected to discover and engineer new biosynthetic pathways to β-lactam antibiotics.
The project will focus mainly on pathways to β-lactams. New approaches will be developed for engineering of β-lactam biosynthesis to produce new types of β-lactams inaccessible by synthesis and thereby reducing the cost of known β-lactamase antibiotics. The project will apply cutting edge biophysical and cell biology techniques to define fundamental gaps in our knowledge in β-lactamase biosynthesis, e.g. the structure and mechanism of key enzymes in penicillin, cephalosporin, clavam, and carbapenem biosynthesis; (ii) apply the new and existing knowledge to illustrate how biosynthetic enzymes can be combined with advanced organic synthesis to generate new generations of β-lactam and related antibiotics and (iii) explore the isolation of novel β-lactam related natural products from microorganisms present in Oman.
The candidate is expected to carryout out experiments, analyze data, prepare presentations, and manuscripts.
The applicant is expected to have the following:
The specific objectives of the work comprise the following:
(i) Penicillin biosynthesis studies and engineering.
(ii) Engineering cephalosporin biosynthesis.
(iii) Understanding the latter stages of carbapenem and clavam biosynthesis.
(iv) Identifying new β-lactam producing strains in Oman.
Position Code: NMSRC_OXU
Application Process: Submit a formal application letter, updated curriculum vitae, list of publications (with impact factor), academic certificates, three letters of references, and contact details in ONE PDF file electronically through the following email: firstname.lastname@example.org
Please note: Position code should be included in the email subject.Continue reading
|Title||Senior Research Scientist in Synthetic Biology involving Discovery and Engineering of New Biosynthetic Pathways to Antibiotics. A joint project between Department of Chemistry, University of Oxford, UK and the Natural and Medical Sciences Research Center|
|Employer||University of Nizwa|
|Job location||Nizwa, Ad Dakhiliyah|
|Published||February 10, 2020|
|Job types||Researcher  |
|Fields||Biophysics,   Molecular Biology,   Microbiology,   Cell Biology,   Chemical Biology,   Synthetic Chemistry  |